Completed PROJECTS

CANCER

• KCNRG as a tumor suppressor gene in CLL and MM
• GE profiling in OVARIAN CARCINOMA, with emphasis on previously uncharcterized Certoli - Leydig Tumor
• Expression level of lipoprotein lipase and dystrophin genes predict survival in B-cell chronic lymphocytic leukemia
• The human T-box mesodermal transcription factor Brachyury is a candidate target for T-cell-mediated cancer immunotherapy
• Cervical intraepithelial neoplasia: Telomerase activity and splice pattern of hTERT mRNA.

Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH)

• Ectopic synthesis of melanin in human adipose tissue
• Profiling of miRNA in the adipose tissue of the morbidly obese patients with NASH and normal liver biopsies
• A role of excessive adipose in the development of the Fibrosis in the patients with Non-Alcoholic SteatoHepatitis (NASH)
• Gene Expression Patterns in the Hepatic Tissue and in the Visceral Adipose Tissue of the Patients with Non-Alcoholic Fatty Liver Disease
• Adipokines and pro-Inflammatory Cytokines in Non-Alcoholic Fatty Liver Disease
• Microarray profiling of the visceral adipose of morbidly obese and lean subjects
• IL28B genotypes influence treatment response in HCV patients
• Gene expression patterns in HCV patients with various ITPA genotypes influencing the development of anemia after IFN/RBV treatment
• Validation of NASH Diagnostics™ panel and its comparison to APRI and ELF/OELF tests in morbidly obese cohort
• Protein pathway activation associated with sustained virologic response in patients with chronic hepatitis C treated with pegylated interferon (PEG-IFN) and ribavirin (RBV).
• Association of Obestatin, Ghrelin, and Inflammatory Cytokines in Obese Patients with Non-alcoholic Fatty Liver Disease.
• Association of serum adipocytokines with hepatic steatosis and fibrosis in patients with chronic hepatitis C

BIOINFORMATICS

• Transcription factor binding site (TFBS) prediction in the complete vertebrate genomes
• Small Interference (si) RNAs with High Specificity to the Target: a Systematic Approach to Design by CRM Algorithm
• Exhaustive algorithms for the prediction of siRNA with minimized off-target hybridization
• Potential regulatory SNPs in promoters of human genes:
  A systematic approach
• In Silico Search for Natural Antisense Transcripts Reveals its Differential Expression in Human Tumors (download PDF)
• KPP: KEGG Pathway Painter
• A network-based approach to prioritize results from genome-wide association studies: use of Google page-rank algorithm in biology

MISCELLANEOUS

• Expression of the repetitive DNA as a marker of cellular stress
• Role of extracellular DNA oxidative modification in radiation induced bystander effects in human endotheliocytes.
• Comparative analysis of the lux operons in Aliivibrio logei KCh1 (a Kamchatka Isolate) and Aliivibrio salmonicida.
• The N-terminal domain of Aliivibrio fischeri LuxR is a target of the GroEL chaperonin.